Objective To construct a hypoglycemia nursing decision support system and to explore its application in clinical practice. Methods This study firstly established a nursing decision support system of hypoglycemia,and realized functions such as intelligent entry,intelligent reminding,and assistant decision making. The medical records before the application of the system(from January to March 2018) and after it(from October to December 2018) were selected to compare the incidences of hypoglycemia and the completion of nursing documents. 117 nurses were enrolled to investigate their satisfaction with the system by self-designed satisfaction questionnaires. Results After applying the hypoglycemia nursing decision support system,the recurrence rate of hypoglycemia decreased from 7.05% to 3.33%,and the difference was statistically significant(χ 2=8.253,P=0.004). The completion rate of nurses’ documents increased from 68.17% to 94.23%,and the difference was statistically significant (χ 2=137.303, P<0.001). 117 questionnaires were collected,and the average score for each dimension was over 2.50. The results showed that nurses were more satisfied with the overall system. Conclusion The establishment of a hypoglycemia nursing decision support system can reduce the recurrence rate of hypoglycemia,improve the quality of clinical nursing documents and the efficiency of clinical nurses,and increase the satisfaction of nurses.